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Authors
Toyama, Tadashi https://orcid.org/0000-0003-0162-6286
Kagimura, Tatsuo
Tanabe, Kenichiro
Iwata, Yasunori
Wada, Takashi
Narita, Ichiei
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Article History
Received: 20 July 2025
Accepted: 13 November 2025
First Online: 29 December 2025
Declarations
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: This study was approved by the Ethics Committee of Niigata University (approval number 2023-0014) and conducted using data collected from the previous BRIGHTEN study. Written informed consent was obtained from all participants in the BRIGHTEN study before enrollment. Patients who participated in BRIGHTEN could opt out of this secondary analysis. The study adhered to the principles of the Declaration of Helsinki.
: Not applicable.
: Competing interestsIchiei Narita received honoraria and subsidies or donations from Kyowa Kirin Co., Ltd.FundingThis study was funded by Kyowa Kirin Co., Ltd. (KKC), which initially proposed the research idea but had no role in data collection, analysis, or interpretation. To ensure impartiality and independence from the principal investigator’s institution, the Translational Research Center for Medical Innovation, an independent third party, was contracted to conduct the study and manage the data.
