Barbieri, Giulia https://orcid.org/0000-0002-3531-0725
Garcia-Larsen, Vanessa https://orcid.org/0000-0002-0003-1988
Lundin, Rebecca https://orcid.org/0000-0002-8380-4834
Fujii, Ryosuke https://orcid.org/0000-0003-1730-2059
Ferraro, Pietro Manuel https://orcid.org/0000-0002-1379-022X
Gambaro, Giovanni https://orcid.org/0000-0001-5733-2370
Melotti, Roberto https://orcid.org/0000-0003-4115-317X
Gögele, Martin https://orcid.org/0000-0003-4785-4348
Cazzoletti, Lucia https://orcid.org/0000-0002-1429-6282
Pramstaller, Peter P. https://orcid.org/0000-0002-9831-8302
Zanolin, Maria Elisabetta https://orcid.org/0000-0003-3021-2269
Pattaro, Cristian https://orcid.org/0000-0002-4119-0109
Hantikainen, Essi https://orcid.org/0000-0002-4155-2894
Article History
Received: 14 October 2025
Accepted: 9 March 2026
First Online: 20 April 2026
Declarations
:
: The Ethics Committee of the Healthcare System of the Autonomous Province of Bolzano-South Tyrol approved the CHRIS baseline protocol on 19 April 2011 (21–2011). The study conforms to the Declaration of Helsinki, and with national and institutional legal and ethical requirements. All participants included in the analysis gave written informed consent.
: GB provided consultancy services to Dr. Schär spa in the past year. CP was consultant for Quotient Therapeutics. PMF received consultant fees and grants or other support from Allena Pharmaceuticals, Alnylam, Amgen, AstraZeneca, Bayer, Gilead, Novo Nordisk, Otsuka Pharmaceuticals, Rocchetta, Vifor Fresenius, and royalties as an author for UpToDate. All other authors declared no conflict of interest.