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Article History

Received: 27 July 2021

Accepted: 29 September 2021

First Online: 29 November 2021

Declarations

:

: This study complies with the guidelines for human studies and was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. Written informed consent was obtained from all participants or their legal surrogate. The Ethics Committee (Catania 1) of University of Catania approved this study.

: All the participants or their legal surrogate gave written consent for their personal or clinical details to be published in this study.

: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Clara G Chisari received a research grant from Sanofi and grant for congress participation from Almiral, Biogen, Merck Serono, Novartis, Roche, Sanofi and TEVA; Simona Toscano declares no conflict of interest; Sebastiano Arena declares no conflict of interest; Chiara Finocchiaro declares no conflict of interest; Arturo Montineri declares no conflict of interest; Francesco Patti has received honoraria for speaking activities by Bayer Schering, Biogen, Merck Serono, Novartis and Sanofi Aventis; he also served as advisory board member the following companies: Bayer Schering, Biogen, Merck Serono, Novartis; he was also funded by Pfizer and FISM for epidemiological studies; he received grant for congress participation from Bayer Schering, Biogen Idec, Merck Serono, Novartis, Roche, Sanofi Aventis and TEVA.