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Article History

Received: 16 February 2022

Accepted: 5 December 2022

First Online: 31 December 2022

Declarations

:

: This study complies with the Declaration of Helsinki and was approved by the Ethics Committee of the Medical Faculty, University of Würzburg (176/13). All patients or their legal representatives provided written informed consent.

: Not applicable.

: F.A.M. is supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) within the UNION-CVD Clinician-Scientist Programme (project number 413657723) and has been previously supported by a MD/PhD Fellowship of the Interdisciplinary Center for Clinical Research, University Hospital Würzburg (project Z-1). E.J.K., V.R., K.U, D.M., T.D. and C.K. have nothing to disclose. S.W. reports grants from the German Ministry of Research and Education and Deutsche Herzstiftung e.V. C.M. reports a research cooperation with the University of Würzburg and Tomtec Imaging Systems funded by a research grant from the Bavarian Ministry of Economic Affairs, Regional Development and Energy, Germany; travel grants, advisory and speakers honoraria from Amgen, Tomtec, Orion Pharma, Alnylam, AKCEA, Boehringer-Ingelheim, Pfizer, SOBI, and EBR Systems; principal investigator in trials sponsored by Alnylam and AstraZeneca; financial support from the Interdisciplinary Center for Clinical Research - IZKF Würzburg (advanced clinician-scientist program). St.St. reports grants from the German Ministry of Research and Education during the conduct of the study; grants and other from Boehringer, Bayer, Thermo Fisher, and Pfizer; other from AstraZeneca, Sanofi, Servier, Alnylam, Ionis, and Akcea; grants, personal fees, non-financial support, and other from Novartis, outside the submitted work. S.F. reports grants from the German Ministry of Research and Education; there is no industrial support competing with the study results. KGH reports speaker’s honoraria, consulting fees, lecture honoraria and/or study grants from Abbott, Amarin, Alexion, AstraZeneca, Bayer Healthcare, Biotronik, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Medtronic, Pfizer, Portola, Premier Research, Sanofi, W.L. Gore and Associates. P.U.H. reports grants from the German Ministry of Education and Research, German Research Foundation, European Union, Berlin Chamber of Physicians, German Parkinson Society, University Hospital Würzburg, Robert Koch Institute, German Heart Foundation, Federal Joint Committee (G-BA) within the Innovationfond, University Hospital Heidelberg (within RASUNOA-prime; supported by an unrestricted research grant to the University Hospital Heidelberg from Bayer, BMS, Boehringer Ingelheim, and Daiichi Sankyo), Charité–Universitätsmedizin Berlin (within Mondafis; supported by an unrestricted research grant to the Charité from Bayer), and University Göttingen (within FIND-AF randomized; supported by an unrestricted research grant to the University Göttingen from Boehringer Ingelheim) outside the submitted work.