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Article History

Received: 18 December 2022

Accepted: 19 January 2023

First Online: 3 February 2023

Declarations

:

: Ethical approval for this study was received in 2021 (the East Midlands—Derby Research Ethics Committee, REC reference: 21/EM/0177) and recruitment started in January 2022. The study has been prospectively registered with the ISRCTN registry (ISRCTN19394828, registered on August 23, 2021). This study is conducted in accordance with the Declaration of Helsinki. All participants are required to provide written informed consent by signing all study form(s), which are witnessed by an appropriately qualified and delegated member of the research team, prior to the completion of all study-specific procedures/investigations. Any protocol amendments will be approved by the appropriate research ethics committee.

: Not applicable.

: HPS. has received support from Guarantors of Brain and the Newcastle Wellcome Trust Translational Partnership for attending conferences. His salary is paid by grants from Parkinson’s UK and Dunhill Medical Trust awarded to the PI AJY. HH: Salary is supported by the NIHR Newcastle clinical Research Facility (CRF) infrastructure. LA’s salary is supported by the NIHR Newcastle Clinical Research Facility (CRF) infrastructure, and LA has received grants from the Economic and Social Research Council (ESRC), Medical Research Council (MRC), Parkinson’s UK, and the Royal College of Radiologists. RW: None. IP: None. EW: None. MRB is employed by the NHS (Newcastle upon Tyne NHS Foundation Trust) and Newcastle University. His research is currently funded by the NIHR, MRC, EPSRC, LifeArc, MNDA and MyName’5 Dodie Foundation. JPT is supported by Newcastle NIHR BRC. He has received speaker fees from GE Healthcare and Bial, has received funding from Sosei-Heptares, and has consulted for Kyowa-Kirin. LR’s research program is supported in part by grants from the MRC, European Union, Parkinson’s UK, NIHR BRC, Cure Parkinson’s Trust, Health Research Council New Zealand, Dunhill Medical, and Stroke Association. AJY is supported by the Newcastle NIHR BRC plus grants from Parkinson’s UK, The Michael J. Fox Foundation, EU IMI, NIHR, Cure Parkinson’s Trust, Lewy Body Society, Intercept Pharmaceuticals, and the Weston Brain Institute. She has received honoraria from Teva-Lundbeck, GE Healthcare, Bial and Parkinson’s Academy and sponsorship from Teva-Lundbeck, UCB, GlaxoSmithKline, Genus, Britannia, and AbbVie for attending conferences.