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Article History

Received: 14 April 2025

Accepted: 27 October 2025

First Online: 24 November 2025

Declarations

:

: Prior to the initiation of the HARMONY trial, the protocol was approved by institutional review boards (Advarra d/b/a Schulman Associates Institutional Review Board, Inc, IRB# 00000971), and all patients or authorized representatives provided written informed consent. The HARMONY trial was conducted in accordance with ethical principles of Good Clinical Practice derived from the Declaration of Helsinki in addition to other applicable and local regulatory requirements.

: Not applicable.

: YT-Y is a speaker and consultant for Abbott, AbbVie, Acadia, Acorda, Amneal, Kyowa Kirin, Sunovion, and Teva. LC , VA , and GB are employees of Acadia Pharmaceuticals Inc.