Crossmark

Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes

Crossref DOI link: https://doi.org/10.1186/s12884-025-07774-y

Published Online: 2025-08-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lebov, Jill Farnell

Nason, Martha

Stolka, Kristen B.

Ximenes, Ricardo

Mussi-Pinhata, Marisa M.

Moye, Jack

Zorrilla, Carmen D.

Velez Vega, Carmen M.

Cordero, José F.

Scalabrin, Deolinda M. F.

Ko, Albert I.

Moreira, Maria Elisabeth Lopes

Galvão, Luiz Augusto

Britt, William

Marques, Ernesto T. A.

Balmaseda, Angel

Harris, Eva

Arias, Juan F.

Schultz-Cherry, Stacey

Garces, Ana Lucía

Krebs, Nancy F.

Ochoa, Theresa J.

Ugarte-Gil, César Augusto

Fogleman, Elizabeth

Gabriel, Erin

Welton, Michael

Irizarry, Carmen M.

de Moura Negrini, Silvia Biason

Coutinho, Conrado Milani

de Barros Miranda-Filho, Demócrito

Montarroyos, Ulisses Ramos

Cordeiro, Marli Tenorio

Gajewski, Anna

Osorio, Jorge E.

Figueroa, Lester
Funding

Funding for this research was provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003, Contracts No. HHSN275201800001I /HHSN27500003, HHSN201800001I/HHSN27500006 and HHSN201800001I/75N94020F00003)

National Institute of Allergy and Infectious Diseases (R01HD061959, R01HD061959, R01AI121207, UM1AI069476, U10HD076474, U01HD052102, P01AI106695, U19AI106772, U01HD040636, HHSN272201400006C and HHSN272201600013C, R01HD061959, R01HD061959, R01AI121207, UM1AI069476, U10HD076474, U01HD052102, P01AI106695, U19AI106772, U01HD040636, HHSN272201400006C and HHSN272201600013C, R01HD061959, R01HD061959, R01AI121207, UM1AI069476, U10HD076474, U01HD052102, P01AI106695, U19AI106772, U01HD040636, HHSN272201400006C and HHSN272201600013C, R01HD061959, R01HD061959, R01AI121207, UM1AI069476, U10HD076474, U01HD052102, P01AI106695, U19AI106772, U01HD040636, HHSN272201400006C and HHSN272201600013C, R01HD061959, R01HD061959, R01AI121207, UM1AI069476, U10HD076474, U01HD052102, P01AI106695, U19AI106772, U01HD040636, HHSN272201400006C and HHSN272201600013C, R01HD061959, R01HD061959, R01AI121207, UM1AI069476, U10HD076474, U01HD052102, P01AI106695, U19AI106772, U01HD040636, HHSN272201400006C and HHSN272201600013C)

Fundação Oswaldo Cruz-Fiocruz, Brazil
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Text and Data Mining valid from 2025-08-30

Version of Record valid from 2025-08-30
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Article History

Received: 2 August 2024

Accepted: 28 May 2025

First Online: 30 August 2025

Declarations

:

: All participating institutions provided ethical review and approval of the study prior to study initiation. Participants provided written informed consent to participate in the study. Age of minority varied by country and sites followed local IRB/IEC requirements for enrollment of minors in the study. If the participant was considered a minor in the participating country, written permission was required from the parent(s)/legal guardian and separate written assent was required from the participating minor. If not possible to obtain written consent, permission, or assent, e.g., due to illiteracy, pregnant participants and their parent(s)/guardian, as appropriate, provided consent, permission, or assent using a fingerprint instead of a signature. The ethics committees of the following institutions provided approval for this study: Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz (Fiocruz Pernambuco); Hospital Geral Roberto Santos; Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz Bahia); Yale University; Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo; University of Alabama at Birmingham; Secretaria Municipal de Saúde do Rio de Janeiro; Instituto Fernandes Figueira, Fundação Oswaldo Cruz (Fiocruz – Rio de Janeiro); University of Wisconsin, Madison; St. Jude Children’s Research Hospital; Universidad de Antioquia, Medellín; Red de Salud de Ladera Empresa Social del Estado; University of Colorado, Denver; Instituto de Nutrición de Centro América y Panamá; Ministerio de Salud Pública y Asistencia Social, Guatemala; Centro Nacional de Diagnóstico y Referencia, Ministerio de Salud, Nicaragua; University of California, Berkeley; University of Puerto Rico, Medical Sciences Campus; University of Georgia, Athens; Hospital Iquitos César Garayar Garcia; Hospital Regional de Loreto Felipe Arriola Iglesias; and Universidad Peruana Cayetano Heredia, RTI International.

: Not applicable.

: The authors declare no competing interests.

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