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Predictive value of the maternal alpha-fetoprotein variant, L2, during the first trimester of pregnancy screening for fetal trisomy 21, trisomy 18, and neural tube defects

Crossref DOI link: https://doi.org/10.1186/s12884-025-07893-6

Published Online: 2025-08-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chen, Yiming

Ning, Wenwen

Wen, Caihe

Gu, Linyuan

Chu, Xuelian
Funding

Funding for this research was provided by:

The Zhejiang Provincial Natural Science Foundation of China's Joint Fund Project (LBY23H200009, LBY23H200009, LBY23H200009)
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Text and Data Mining valid from 2025-08-13

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Article History

Received: 9 June 2024

Accepted: 30 June 2025

First Online: 13 August 2025

Declarations

:

: The study was approved by Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital) ethics committee, and the approval number was [2023]- Medical Review A (002). The data used in this study was anonymised before its use. Patients’ consents were not required because this was a retrospective study.

: Not applicable; this was a retrospective study and no individual person’s personal information is included.

: The authors declare no competing interests.

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