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Testing the use of a biomarker (PlGF) to evaluate superimposed preeclampsia in pregnant women with chronic hypertension (B.I.P.E.S.): a randomized clinical trial study protocol

Crossref DOI link: https://doi.org/10.1186/s12884-025-08592-y

Published Online: 2025-12-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Japecanga, Rodolfo Rosa

da-Costa-Santos, Juliana

Nobrega, Guilherme Moraes

Sousa, Ana Beatriz

Guimarães, Fernando

Surita, Fernanda G.

de Siqueira Guida, José Paulo

Costa, Maria Laura
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Text and Data Mining valid from 2025-12-26

Version of Record valid from 2026-03-11
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Article History

Received: 30 June 2025

Accepted: 11 December 2025

First Online: 26 December 2025

Declarations

:

: This research protocol has been approved by the National Ethical Committee of Research in Health, CONEP (CAAE:77909823.0.0000.5404) and registered in the national platform of clinical trials, ReBEC (RBR-2zx5y9r).

: All participants will sign the Informed Consent Form, with authorization for deidentified data sharing.

: The authors declare no competing interests.

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