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Article History

Received: 20 December 2017

Accepted: 18 April 2018

First Online: 27 April 2018

Ethics approval and consent to participate

: Institutional review board approval was waived by the responsible Ethics Committee of the Medical Association of Rhineland Palatinate, Mainz, Germany, given the retrospective study design and analysis of clinical data. Additional examinations were not performed. Patient records and information were anonymized and de-identified prior to analysis.

: PRG has received grants and personal fees from Bayer, personal fees from Bristol-Myers Squibb, personal fees from MSD Sharp & Dohme, personal fees from Lilly, personal fees from Sillajen, personal fees from SIRTEX, and personal fees from AstraZeneca. IS has received grants from Merck Serono. AW has received speaker fees and travel grants from Bayer. RK has received speaker fees from SIRTEX and personal fees from Guerbet and Bristol-Myers Squibb. None of these companies supported this study and none of the authors reports a conflict of interest.

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