Document is current

Article History

Received: 21 June 2017

Accepted: 30 April 2018

First Online: 8 May 2018

Ethics approval and consent to participate

: The authors follow either the Declaration of Helsinki to protect the patients, and the trial will be performed according to the ICH-GCP guidelines. The institutional review board of the principal investigator (S-H Lee) approved the trial (KHNMC 2016-04-042-001) at Kyung Hee University Hospital at Gangdong. Moreover, the full lists of ethics committees that approved the trial are as follows: IRB 2016-106 at Chuncheon Sacred Heart Hospital, CR316102 at Wonju Severance Christian Hospital, IRB 2016-11-015 at Chungnam National University Hospital, IRB 2017-02-053 at Kyung Hee Medical Center, WKUH 2017-02-008-001 at Wonkwang University Hospital, IRB 16-0242 at Inje University Busan Paik Hospital, SGPAIK 2016-09-001-004 at Inje University Sanggye Paik Hospital, DSMC 2016-09-022-001 at Keimyung University Dongsan Medical Center, IRB 3-2017-0019 at Gangnam Severance Hospital, IRB 05-2016-179 at Pusan National University Yangsan Hospital, IRB 2017-4239-0001 at Seoul St. Mary’s Hospital. All patients will understand and agree to the aims and process of the trial, possible results and risks. An informed consent has to be written in the language which patients can understand, and be explained by an investigator. If patients cannot read an informed consent, an investigator has to read it in the presence of a witness. Although a patient signed an informed consent at first, an investigator has to stop a process of the patient when he or she refuses. A copy of signed informed consent should be provided to the patient. An original copy will be an investigator’s safekeeping.

: The authors declare that they have no competing interests.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.