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Article History

Received: 17 May 2018

Accepted: 27 July 2018

First Online: 6 August 2018

Ethics approval and consent to participate

: All patients declared written consent. The CRC study was approved by local ethics committee of the University of Kiel (AZ 110/99), Germany. The use of patient materials for the DZL study was approved by local ethics committee of the University of Lübeck (AZ 12–220), Germany.The OLP study design complied with the Declaration of Helsinki, and was approved by the ethics board of the Christian-Albrecht-University of Kiel, Germany (reference number: D 426/08). All patients gave written informed consent upon inclusion into the study.

: Not applicable.

: The authors declare that they have no competing interests.

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