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Taxifolin, a natural flavonoid interacts with cell cycle regulators causes cell cycle arrest and causes tumor regression by activating Wnt/ β -catenin signaling pathway

Crossref DOI link: https://doi.org/10.1186/s12885-018-4959-4

Published Online: 2018-10-26

Published Print: 2018-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Razak, Suhail

Afsar, Tayyaba

Ullah, Asad

Almajwal, Ali

Alkholief, Musaed

Alshamsan, Aws

Jahan, Sarwat
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Text and Data Mining valid from 2018-10-26
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Article History

Received: 1 August 2018

Accepted: 16 October 2018

First Online: 26 October 2018

Ethics approval and consent to participate

: Athymic nude mice studies were performed according to the Institutional principles for the concern and use of animals and the experimental protocol was approved (BAS#0256) by the ethical board of Quaid-i-Azam University, Islamabad, Pakistan and Committee dealing animal care and use, college of Pharmacy, King Saud University, Kingdom of Saudi Arabia. Before starting experiment on human colorectal cancer cell lines HCT116 and HT29 (ATCC® CCL-247 ™ and ATCC® HTB-38 ™ respectively) purchased in July 2017 from American Type Culture Collection (MD, USA), ethical approval was taken from ethics committee of preclinical studies, college of pharmacy, King Saud University, KSA.

: Not applicable.

: The authors declare that they have no competing interests.

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