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Article History

Received: 7 February 2018

Accepted: 12 April 2019

First Online: 28 May 2019

Ethics approval and consent to participate

: Documented approval from the appropriate ethics committees/institutional review boards (IRB) of the Medical Faculty of the Heidelberg University (main IRB) and all participating study sites has been obtained prior to study start and a data safety monitoring board (DSMB) has been installed to monitor the trial. Written informed consent from each patient is obtained before any study-specific procedures are performed. A full list of involved/ local ethicscommittees is provided in the accepting assessment documents in a separate file.

: At this time (04/05/2018), only abstracts regarding the HD6 trial have been published (e.g. ASH Abstract 2016:Evaluation of Stem Cell Mobilization in Patients with Multiple Myeloma after Lenalidomide-Based Induction Chemotherapy within the GMMG-HD6 Trial; P Wuchter et al; Blood 2016 128:3373). The trial protocol has not been openly published in a peer reviewed paper.

: Author-specific disclosures: HS: Celgene: Honoraria, Travel grants; Bristol Myers Squibb: Honoraria and Research Funding; Amgen: Honoraria, Travel grants; Janssen: Honoraria and Research Funding; Novartis: Honoraria and Research Funding; Takeda: Honoraria. KW: Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees and Research Funding; Bristol Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees and Research Funding; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees and Research Funding; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees and Research Funding Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees and Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees and Research Funding; Sanofi: Research Funding. JD: Celgene: Honoraria, Research Funding and Speakers Bureau; Janssen: Honoraria and Speakers Bureau . MSR: Celgene: Honoraria, Research Funding, Speakers Bureau; Bristol Myers Squibb: Consultancy and Speakers Bureau; Amgen: Honoraria, Research Funding, Speakers Bureau; Novartis: Consultancy and Research Funding; Morphosys: Research Funding. JH: Celgene: Consultancy, Honoraria and Membership on an entity's Board of Directors or advisory committees; Bristol Myers Squibb: Honoraria; Amgen: Consultancy, Honoraria and Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria and Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria and Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria; Sanofi: Research Funding. DH: Celgene: Consultancy, Research Funding; MM: Janssen: Consultancy; Bristol Myers Squibb: Consultancy; Takeda: Consultancy; Amgen: Consultancy Celgene: Consultancy. RF: Celgene: Consultancy, Honoraria, Research Funding; Amgen: Consultancy, Honoraria. MHa: Roche: Honoraria; Novartis: Honoraria. HG: Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding and Speakers Bureau; Chugai: Consultancy, Honoraria and Research Funding; Bristol Myers Squibb: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding and Speakers Bureau Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding and Speakers Bureau; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding and Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding and Speakers Bureau; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding and Speakers Bureau. All other authors declare no conflict of interest.

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