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Article History

Received: 8 December 2018

Accepted: 5 July 2019

First Online: 22 July 2019

Ethics approval and consent to participate

: All animal studies were conducted at Crown Bioscience SPF facility under sterile conditions and were in strict accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. Protocols of all studies were approved by the Committee on the Ethics of Animal Experiments of Crown Bioscience, Inc. (Crown Bioscience IACUC Committee).

: Not applicable.

: This research was funded by Crown Bioscience Inc. and all authors were employees thereof at the time the study was performed. The authors declare no other competing interests.