Weber, Sarah
Koschade, Sebastian E.
Hoffmann, Christopher M.
Dubash, Taronish D.
Giessler, Klara M.
Dieter, Sebastian M.
Herbst, Friederike
Glimm, Hanno
Ball, Claudia R. https://orcid.org/0000-0002-1749-3791
Funding for this research was provided by:
Deutsches Krebsforschungszentrum (NCT3.0_2015.04 TransOnco, NCT3.0_2015.54 DysregPT)
Deutsche Krebshilfe (Colon-Resist-Net, Colon-Resist-Net)
TRANSCAN-2 ERA-NET (TACTIC)
Article History
Received: 21 August 2019
Accepted: 22 November 2019
First Online: 3 December 2019
Ethics approval and consent to participate
: Primary human CRC tissue or derived metastases were obtained at the University Hospital Heidelberg in accordance with the Declaration of Helsinki. The patients signed informed consent as approved by the Ethics Review Board of the Medical Faculty, University of Heidelberg (approval number 323–2004).All animal experiments performed in this study were conducted according to the national guidelines and were reviewed and confirmed by an institutional review board/ethics committee headed by the responsible animal welfare officer. The Regional Authority of Karlsruhe, Germany finally approved the study protocol involving xenotransplantation of human derived tissue in immune deficient mice as the responsible national authority (approval numbers G-129/07 and G-228/12).
: Not applicable.
: The authors declare that they have no competing interests.