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Article History

Received: 27 May 2020

Accepted: 9 June 2020

First Online: 15 June 2020

Ethics approval and consent to participate

: The study will be conducted according to the ICH Harmonised Tripartite Guideline for Good Clinical Practice and has been approved by the medical ethics committee of the Maastricht University Medical Centrum (MUMC)/Maastricht University (no: 18–068). All patients will receive oral and written information about the study. They are given sufficient time to consider participation before the informed consent will be signed. The sponsor/investigator has a liability insurance which is in accordance with article 7 of the WMO in the Netherlands. This insurance provides cover for damage to research subjects through injury or death caused by the study. The insurance applies to the damage that becomes apparent during the study or within 4 years after the end of the study.

: Not applicable.

: PL reports, inside the submitted work, grants/sponsored research from Oncoradiomics, ptTheragnostic/DNAmito; advisor (SAB)/presentor fee from Oncoradiomics, Varian medical and Elekta. Furthermore, he is the inventor of two patents on radiomics and one non-patentable invention (software), licensed to Oncoradiomics and has (minority) shares in the company Oncoradiomics and MedC2. LH: none related to the current manuscript, outside of current manuscript: research funding Roche, Boehringer Ingelheim, AstraZeneca (all institution), the advisory board: Boehringer, BMS, Lilly, Takeda, Pfizer, MSD (all institution), travel reimbursement: Roche, BMS (self); mentorship program with key opinion leaders: funded by AstraZeneca; fees for educational webinars: Quadia (self). Philogen S.P.A supplies L19-IL2 (darleukin). Philogen had only influence on the drug-related topics in the study protocol, e.g. description, preparation, labelling, and justification of administration and dosage. DN: reports he is a co-Founder and Board Member in Philogen. DdR: none related to the current manuscript, outside of the current manuscript: advisory board of Bristol-Myers-Squibb, Astra Zeneca, Roche/Genentech, Merck/Pfizer and Celgene. Research grants have been received from Bristol-Myers Squibb and Boehringer Ingelheim. All income from the advisory board and from the research grants went integrally to the institution. AD: none related to the current manuscript, outside of the current manuscript: advisory board BMS, MSD, Roche, Eli Lilly, Takeda, Pfizer, Boehringer Ingelheim (all institution). Research grant: BMS (institution). YL: personal fees from Astra Zeneca, personal fees from RayStation, outside the submitted work. AA reports grants and other benefits from Merck, EMD and Fibrogen, and other benefits from BMS, BioMedX and Roche, outside the submitted work. All other authors declare that they have no competing interests.