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Article History

Received: 5 February 2020

Accepted: 15 June 2020

First Online: 30 June 2020

Ethics approval and consent to participate

: Non-clinical samples were de-identified, and obtained from various institutions that had a Materials Transfer Agreement (MTA) in place. Written consent was provided on site, per the MTA. Consent for clinical samples to be used in these studies was obtained from patients via their consent to enroll in the clinical trials that supplied the samples for analysis, as required by trial methodology. Clinical trials were conducted ethically and in accordance with the Declaration of Helsinki, were registered with the Western Institutional Review Board (WIRB), and satisfied Institutional Review Board (IRB) requirements (ADAP-002). WIRB is registered with the Office for Human Research Protections (OHRP) and the FDA, and operates in compliance with FDA regulations 21 CFR Parts 50 and 56, HHS regulations 45 CFR 46, the International Conference on Harmonization (ICH) E6, and Good Clinical Practice (GCP) where applicable. IRB registration number IRB00000533, parent organization number IORG0000432.

: Not applicable.

: TC is an employee of Adaptive Biotechnologies Corporation. MED, TE, MMEM, JMT, MSS, RPB, SV, NKA, IRK, ROE, MV, TM, CS and BH are employed by, and have financial interests in Adaptive Biotechnologies. MEM and BMC have financial interests in Adaptive Biotechnologies. DW and PLS have received consulting fees from Adaptive Biotechnologies Corporation. HSR and AS are employed by, own stock in, and hold patent(s) and/or are receiving royalties from Adaptive Biotechnologies Corporation.