Document is current

Article History

Received: 24 July 2019

Accepted: 29 January 2020

First Online: 11 February 2020

Ethics approval and consent to participate

: This study was approved by the ethical review board of Hyogo Cancer Center (approval reference number R-111), the ethical review board of Saitama Cancer Center (approval reference number CA013–22), and the Ethics Committee, Osaka International Cancer Institute (approval reference number 1311253188). This study was conducted in accordance with the ethical principles in the Declaration of Helsinki. The study has been registered under the University Medical Hospital Information Network (UMIN) Clinical Trials Registry: identifier UMIN 000011776. All patients provided written informed consent before enrollment. The informed consent form also contained an agreement for the publication of the study results.

: Not applicable.

: YH has received grants and personal fees from Ono Pharmaceutical and MSD as well as personal fees from AstraZeneca, Boehringer Ingelheim, Chugai Pharmaceutical, Eli Lilly, Novartis and Taiho Pharmaceutical. TI has received personal fees from AstraZeneca, Chugai Pharmaceutical, Ely Lilly, MSD and Ono Pharmaceutical. TK has received grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chugai Pharmaceutical, Eli Lilly, MSD, Novartis, Ono Pharmaceutical, Pfizer, and Taiho Pharmaceutical as well as grants from Merck Serono, Regeneron Pharmaceuticals, and Takeda Pharmaceutical as well as personal fees from Bristol-Myers Squibb and TEIJIN PHARMA. KN has received grants and personal fees from Boehringer Ingelheim as well as personal fees from AstraZeneca and Chugai Pharmaceutical. RU has received personal fees from Eisai and CAC Croit. SM has received grants and personal fees from Boehringer Ingelheim as well as personal fees from AstraZeneca, Bristol-Myers Squibb, Chugai Pharmaceutical, Eli Lilly, MSD, Ono Pharmaceutical, Pfizer and Taiho Pharmaceutical. FI has received grants and personal fees from AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Chugai Pharmaceutical, MSD, and Ono Pharmaceutical as well as personal fees from Eli Lilly, Kyowa Hakko Kirin, Novartis, Pfizer and Taiho Pharmaceutical. MS has received grants and personal fees from AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Chugai Pharmaceutical, Eli Lilly, MSD, Novartis, Ono Pharmaceutical, and Pfizer as well as grants from AbbVie and Ignyta. All remaining authors have declared no conflicts of interest.