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Authors
Eppenberger-Castori, Serenella https://orcid.org/0000-0003-2194-2913
Klingbiel, Dirk
Ruhstaller, Thomas
Dietrich, Daniel
Rufle, Daniel Alexander
Rothgiesser, Karin
Pagani, Olivia
Thürlimann, Beat
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Funding
Funding for this research was provided by:
Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK99/22)
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Article History
Received: 22 June 2019
Accepted: 31 January 2020
First Online: 11 February 2020
Ethics approval and consent to participate
: Swissmedic Nr: 1999S003229.Swissmedic Authorisation date (IKS at that time): 18.08.1999.Ethic committee Ticino for Istituto Oncologico della Svizzera Italian (IOSI) and Ospedale Regionale di Lugano Civico.Kantonale Ethikkommission Bern for Inselspital and STS AG Thun, reference number 111/99.Ethikkommission Nordwest- und Zentralschweiz (EKNZ) for Kantonsspital Aarau, Kantonsspital Baden, Universitätsspital Basel and Praxis Dr. K. Beretta, reference number M158/99.Ethikkommission Ostschweiz (EKOS) for Kantonsspital St. Gallen.Ethikkommission Zürich for Kantonsspital Graubünden, Stadtspital Triemli, Stadtspital Waid and Universitätsspital Zürich, reference number 59S.Commission Cantonale d’Ethique de la Recherche sur l’être humain (CCER) for Hôpitaux Universitaires de Genève.Commission cantonale d’éthique de la recherche sur l’être humain (CER-VD) for Centre hospitalier universtaire vaudois (CHUV), reference number F92/99.Comitato etico from the Istituto Europeo di Oncologia (IEO).Comitato etico from the Ospedale di Circolo e Fondazione Macchi.The study number received from some Ethical Committees is missed since at that time this did not apply.All patients gave written inform consent and could disenroll from the study at any time. Indeed, we destroyed the blood samples of the two patients who retrieved their consent after blood donation.
: The SAKK board approved the publication of this manuscript.
: Dirk Klingbiel performed the statistical analysis of the data working for the SAKK Swiss Group for Clinical Cancer Research Coordinating Center, Bern, Switzerland. Thereafter, before submission of the manuscript, he joined F. Hoffmann-La Roche Ltd. (F. Hoffmann-La Roche Ltd., Global Product Development Medical Affairs (Biometrics), CH-4053 Basel).D.A. Rufle joined Ausbilder Biologie, AZM-2202.2.04, Lachmattstrasse 81, 4132 Muttenz after complete performance of all laboratory analyses.B. Thürlimann holds stock of Roche and received honoraria for consultations from Roche.All other authors declare that they have no competing interests.
