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Article History

Received: 2 September 2021

Accepted: 13 January 2022

First Online: 3 March 2022

Declarations

:

: Both the GOYA and CAVALLI studies were conducted in accordance with the European Clinical Trial Directive (for European centers), Declaration of Helsinki and the International Conference on Harmonisation guidelines for Good Clinical Practice. The GOYA and CAVALLI protocols were approved by the ethics committees of participating centers; further details of these are provided in Supplementary Table InternalRef removedA and InternalRef removedB. Both protocols are registered at ClinicalTrials.gov. All patients provided written informed consent.The real-world DLBCL cohort was drawn from the nationwide (US only) Flatiron Health-Foundation Medicine clinic-genomic database (FH-FMI CGDB). The de-identified data originated from approximately 280 cancer clinics (~800 sites of care) in the US; data for this analysis were derived from a subset of patients who underwent FMI F1H [CitationRef removed] comprehensive genomic profiling based on their electronic health record [CitationRef removed, CitationRef removed]. Retrospective longitudinal clinical data were derived from electronic health record data, comprising patient-level structured and unstructured data, curated via technology-enabled abstraction, and linked to genomic data derived from FMI comprehensive genomic profiling tests in the FH-FMI CGDB by de-identified, deterministic matching [CitationRef removed, CitationRef removed].

: Not applicable.

: E.K: employment (Genentech Inc.), ownership interests (F. Hoffmann La-Roche Ltd). T.X: employment (F. Hoffmann La-Roche Ltd). C.R.B: employment (Genentech Inc.), ownership interests (F. Hoffmann La-Roche Ltd). A.B: employment and ownership interests (Roche Products Ltd). Y.J: employment (Genentech Inc.), ownership interests (Genentech, Inc., F. Hoffmann La-Roche Ltd). A.K. employment (F. Hoffmann-La Roche Ltd). K.H: employment (Roche Products Ltd). T.G.N: employment and ownership interests (F. Hoffmann-La Roche Ltd). E.P: employment (Genentech, Inc.), ownership interests (F. Hoffmann La-Roche Ltd). J.N.P: employment (Genentech, Inc.), ownership interests (F. Hoffmann La-Roche Ltd).