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Article History

Received: 14 January 2022

Accepted: 14 March 2022

First Online: 18 March 2022

Declarations

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: This study was conducted in accordance with the Declaration of Helsinki and was approved by the institutional ethics review board of Dokkyo Medical University Hospital (approval no. 24017.R-6–5.). Before surgery, written consent regarding the use of surgical samples and blood, as well as data publication was requested, and protection of patient privacy in future studies was guaranteed through a signed consent form approved by our institutional Committee on Human Rights in Research. Surviving patients provided written consent for analysis using the surgical samples, through a signed form approved by our institutional Committee on Human Rights in Research. All clinical samples were anonymized before analysis to guarantee protection of patient privacy. Consequently, each patient in this cohort signed the consent form approved by our institutional Committee on Human Rights in Research (approval no. 24017.R-6–5.).

: Each patient signed an informed consent and subsequent publication form that was approved by our institutional Committee on Human Rights in Research. All clinical samples were anonymized before analysis to guarantee protection of patient privacy.

: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.