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Article History

Received: 25 October 2022

Accepted: 26 April 2023

First Online: 19 May 2023

Declarations

:

: The study had approvals by the UK National Health Service (NHS) Health Research Authority (HRA) (Reference: 19/HRA/0376) and the Medical Research Council, Scientific and Research Ethics Committee in Hungary (ETT-TUKEB) (Reference: OGYÉI/46651–4/2020). The study was performed in accordance with the principles outlined in the Declaration of Helsinki for all human experimental investigations. The need for informed consent to participate was reviewed by HRA and ETT-TUKEB and confirmed to not be required as the study involved secondary use of retrospective and pseudonymised data.

: Not applicable.

: All authors have completed the ICMJE uniform disclosure form. The following authors are paid employees of the company: Annie Y. Ng, Galvin Khara, Georgia Fox, Ben Glocker, Edit Karpati, Tobias M. Rijken, Joseph E. Yearsley, Peter D. Kecskemethy. The following were paid employees of Kheiron at the time of the study: Christopher C. Austin, Andreas Heindl, Vignesh Venkataraman. Eva Ambrozay and Gabor Forrai are paid consultants of Kheiron. Other authors did not receive payment for this work and do not have competing interests.