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Article History

Received: 22 July 2024

Accepted: 3 March 2025

First Online: 18 March 2025

Declarations

:

: This study was approved by each center’s ethics committee or institutional review board, and the study was conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines. All participants provided written informed consent. List of independent Ethics Committees/Institutional Review Boards with dates of approval: (1) University Health Network Research Ethics Board, 700 Bay Street, 17th Floor, Suite 1700, M5G 1Z6, Toronto, Ontario, CANADA (Approval: 12-Oct-2017); (2) Dana Farber Cancer Institute/Dana-Farber/Harvard Cancer center, 450 Brookline Ave, OS-200, Boston, MA, 02215, UNITED STATES (Approval: 07-Nov-2017); (3) Western Institutional Review Board, 1019 39th Avenue SE, Ste 120, Puyallup, WA, 98374, UNITED STATES (Approval: 18-Oct-2017); (4) Peter MacCallum Cancer Centre Ethics Committee, 305 Grattan Street, 3000, Melbourne, Victoria, AUSTRALIA (Approval: 01-Aug-2018); (5) IntegReview Ethical Review Board, 3001 S. Lamar Blvd., Suite 210, Austin, TX, 78704, UNITED STATES (Approval: 03-Sept-2018).

: Not applicable.

: Authors with affiliations 1-4 are employees and/or shareholders of F Hoffmann-La Roche. All authors have received grants and non-financial or other support from F. Hoffmann-La Roche, during the conduct of the study. Editorial support, funded by the sponsor, was provided by an independent medical writer under the guidance of the authors.