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Brain-derived neurotrophic factor and cytokines as predictors of cognitive impairment in adolescent and young adult cancer patients receiving chemotherapy: a longitudinal study

Crossref DOI link: https://doi.org/10.1186/s12885-025-14430-3

Published Online: 2025-07-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Trudeau, Julia

Ng, Ding Quan

Sayer, Michael

Tan, Chia Jie

Ke, Yu

Chan, Raymond J.

Chan, Alexandre
Funding

Funding for this research was provided by:

National Institutes of Health (R01CA276212, R01CA276212, R01CA276212, R01CA276212)

National Medical Research Council (NMRC/CIRG/1471/2017, AC, NMRC/CIRG/1471/2017, AC, NMRC/CIRG/1471/2017, AC, NMRC/CIRG/1471/2017, AC)
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Article History

Received: 14 April 2025

Accepted: 2 June 2025

First Online: 1 July 2025

Declarations

:

: The study received ethics approval from the SingHealth Centralized Institutional Review Board (CIRB 2017/3139) and informed consent was obtained prior to study participation (ClinicalTrials.gov: NCT03476070). All experiments were performed in accordance with relevant human subject guidelines and regulations, including ethical principles outlined in the Belmont Report and legal mandates outlined in Singapore’s Human Biomedical Research Act (HBRA) and the International Conference for Harmonization Guidelines for Good Clinical Practice (ICH GCP).

: Not applicable.

: The authors declare no competing interests.

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