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Elucidating a novel prognostic signature for bladder cancer by integrating hypoxia and lactate metabolism-related genes: comprehensive bioinformatics analyses and experimental evidence

Crossref DOI link: https://doi.org/10.1186/s12885-025-15010-1

Published Online: 2025-11-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhao, Yihao

Li, Peixin

Shen, Zhe

Yao, Shengwen

Zhang, Xiaoyi

Zhang, Nianzhao

Chen, Jun
Funding

Funding for this research was provided by:

Qingdao Municipal Science and Technology Bureau (Grant No. 21-1-4-rkjk-7-nsh)

Natural Science Foundation of Shandong Province (Grant No.ZR2023MH231)
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Text and Data Mining valid from 2025-11-21

Version of Record valid from 2025-11-21
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Article History

Received: 7 July 2025

Accepted: 8 September 2025

First Online: 21 November 2025

Declarations

:

: This study was approved by the Ethics Committee of Qilu Hospital of Shandong University (Approval No.: KYLL-202407(X)-Z046-1). Our study obtained informed consent from all participants and was in compliance with the Helsinki Declaration.

: Not applicable.

: The authors declare that they have no competing interests.

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