Brédart, Anne https://orcid.org/0000-0002-1864-5371
Kop, Jean-Luc https://orcid.org/0000-0002-6963-8411
Shamieh, Omar https://orcid.org/0000-0002-3635-8624
Fox, Louis https://orcid.org/0000-0002-8280-1797
Alrjoub, Waleed https://orcid.org/0000-0001-6098-9891
Conroy, Thierry https://orcid.org/0000-0001-7548-284X
Turhal, Nazim Serdar https://orcid.org/0000-0002-1013-5676
Arraras, I. Juan https://orcid.org/0000-0002-4415-2570
Bultijnck, Renée https://orcid.org/0000-0003-4122-2323
Harle, Amélie https://orcid.org/0000-0001-7743-9626
Van Hemelrijck, Mieke https://orcid.org/0000-0002-7317-0858
Pinto, Eleonora https://orcid.org/0000-0001-5404-5958
Roth, Eric J. U. https://orcid.org/0000-0003-1909-2462
Ioannidis, Georgios https://orcid.org/0000-0003-2535-7279
Costantini, Anna https://orcid.org/0000-0002-5955-5209
Chalk, Tara https://orcid.org/0000-0003-2964-1891
Young, Teresa https://orcid.org/0000-0003-0367-2980
Rohde, Gudrun https://orcid.org/0000-0002-8538-7237
Ishiki, Hiroto https://orcid.org/0000-0002-0800-2161
Kikawa, Yuichiro https://orcid.org/0000-0002-3852-5991
Schmidt, Heike https://orcid.org/0000-0002-0922-4022
Vassiliou, Vassilios
Shayler, Stephanie
Marchal, Frédéric https://orcid.org/0000-0002-7685-6070
Amélie, Anota
Lehmann, Jens https://orcid.org/0000-0002-4670-7517
,
Funding for this research was provided by:
European Organisation for Research and Treatment of Cancer (007-2018)
Article History
Received: 23 July 2025
Accepted: 26 September 2025
First Online: 26 November 2025
Declarations
:
: The study was performed according to the rules of the Helsinki-declaration. It received ethical approval from the coordinating centre (Committee for the Protection of Persons/”Comité de Protection des Personnes” Nord-Ouest 1: 15/11/2019) and from each participating center according to national and regional requirements, and is registered in ClinicalTrials.gov under ID: NCT05989191. Written informed consent to participate was obtained from all of the participants in the study.
: Not applicable.
: Jens Lehmann reports consultancy for Evaluation Software Development (ESD) and a research grant from Takeda Austria and Germany, both outside of the submitted work. All other authors report no competing interest.