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Is active surveillance of CIN2 always appropriate? Clinical outcomes and factors associated with progression and regression over 48 months in an HPV-positive cohort

Crossref DOI link: https://doi.org/10.1186/s12885-026-16398-0

Published Online: 2026-06-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Bruno, Maria Teresa

Pagana, Alessia

Aiello, Tiziana

Pivetti, Elena

Cavallaro, Antonino Giovanni

Tarascio, Mattia

Panella, Marco Marzio

Valenti, Gaetano
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Text and Data Mining valid from 2026-06-22

Accepted Manuscript valid from 2026-06-22
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Article History

Received: 26 March 2026

Accepted: 18 June 2026

First Online: 22 June 2026

Declarations

:

: This study conforms to the principles of the Declaration of Helsinki, as revised in 2013. Based on Italian law, the University Hospital’s ethics committee (Catania 2), Azienda Ospedaliero-Universitaria Policlinico Rodolico–San Marco, Catania, Italy, waived the requirement for ethical approval and informed consent because the study used previously archived data, according to current legislation (20 March 2008) (AIFA): (accessed on 12 December 2025).

: Not applicable.

: The authors declare no competing interests.

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