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Authors
Vilella, Thainá
Nunes, Beatriz Carvalho
Del Valle, Giulia Steuernagel
Pinheiro, Isabel Furquim
Aoi, Hiromi
Mizuguchi, Takeshi
Seyama, Rie
Uchiyama, Yuri
Matsumoto, Naomichi
Kim, Chong Ae
Sallum, Juliana Maria Ferraz
Melaragno, Maria Isabel
Cristovam, Priscila Cardoso
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Funding
Funding for this research was provided by:
Fundação de Amparo à Pesquisa do Estado de São Paulo (2019/21644-0, 2019/21644-0, 2019/21644-0, 2019/21644-0)
JSPS KAKENHI (JP23K27568, JP23K18278, JP23K07229, and JP24K02230, JP23K27568, JP23K18278, JP23K07229, and JP24K02230, JP23K27568, JP23K18278, JP23K07229, and JP24K02230, JP23K27568, JP23K18278, JP23K07229, and JP24K02230, JP23K27568, JP23K18278, JP23K07229, and JP24K02230)
Takeda Science Foundation
AMED (JP24ek0109674, JP24ek0109760, JP24ek0109617, JP24ek0109648 and JP24ek0109677, JP24ek0109674, JP24ek0109760, JP24ek0109617, JP24ek0109648 and JP24ek0109677, JP24ek0109674, JP24ek0109760, JP24ek0109617, JP24ek0109648 and JP24ek0109677, JP24ek0109674, JP24ek0109760, JP24ek0109617, JP24ek0109648 and JP24ek0109677, JP24ek0109674, JP24ek0109760, JP24ek0109617, JP24ek0109648 and JP24ek0109677)
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Article History
Received: 23 January 2025
Accepted: 11 September 2025
First Online: 14 October 2025
Declarations
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: This study was approved by the Ethics Committee of the Universidade Federal de São Paulo/UNIFESP (CAAE nº 53275421.0.0000.5505; CEP/UNIFESP nº 1300/2021) and is in accordance with the Declaration of Helsinki. Written informed consent was obtained from the parents/legal guardians of patients under 16 years of age and illiterate participants.
: Written informed consent was obtained from the patients and their legal guardians for publication of their personal, clinical, genetic and identifying image data in this study.
: The authors declare no competing interests.
