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Emotional and behavioural symptoms in childhood (aged 8–14) and severity of mental illness outcomes in young adults: a retrospective observational study using cross-sectional data from electronic health records in the clinical practice research datalink (CPRD)

Crossref DOI link: https://doi.org/10.1186/s12887-025-06425-7

Published Online: 2026-01-16

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Pascual-Sanchez, Ana

Greenfield, Geva

Creese, Hanna-Marie

Saxena, Sonia

Hargreaves, Dougal

Nicholls, Dasha
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Text and Data Mining valid from 2026-01-16

Version of Record valid from 2026-04-02
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Article History

Received: 4 August 2025

Accepted: 27 November 2025

First Online: 16 January 2026

Declarations

:

: The present study was approved by the Medicines & Healthcare products regulatory Agency, who granted access to a subset of the Clinical Practice Research datalink (CPRD). ISAC Protocol number: 20_000097. In CPRD (Clinical Practice Research Datalink) research, consent to participate is handled in a way, that since GP practices contribute data to CPRD, while individual patient consent isn’t needed for this initial data sharing due to anonymization, patients can choose to opt out of having their data shared. CPRD provides access to anonymized primary care data for research purposes. In order to do research studies using CPRD data, the study has to be approved by the Medicines & Healthcare products regulatory agency, and access was granted. CPRD has a rigorous Research Data Governance (RDG) process that ensures research using its data adheres to ethical principles, including the Declaration of Helsinki. Researchers must apply for access and receive approval before using CPRD data for research, ensuring data protection.

: details as above, further consent declaration not applicable.

: The authors declare no competing interests.

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