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Article History

Received: 5 July 2017

Accepted: 7 January 2018

First Online: 26 January 2018

Ethics approval and consent to participate

: The study was carried out in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. Ethical approval was granted by the National Health Service Research Ethics Committee (project ID 97546). Written informed consent was obtained for all participants over the age of 16 and written consent from a parent/legal guardian was obtained for younger participants together with their assent.

: Not applicable.

: PF is in receipt of a National Institute for Health Research (NIHR) Senior Investigator Award (NF-SI-0514-10,157), and he was in part supported by the NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) North Thames at Barts Health NHS Trust. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. EB is employed half-time by the University of Cambridge and half-time by GlaxoSmithKline; he also holds stock in GSK.

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