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Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial

Crossref DOI link: https://doi.org/10.1186/s12888-026-07903-7

Published Online: 2026-03-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Mosavat, Seyed Hamdollah

Sahraian, Ali

Kalani, Mehdi

Namjoyan, Foroogh

Ghasemi, Younes
License Information

Text and Data Mining valid from 2026-03-13

Version of Record valid from 2026-04-21
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Article History

Received: 27 May 2025

Accepted: 9 February 2026

First Online: 13 March 2026

Declarations

:

: This study was conducted in accordance with ethical principles and guidelines for research involving human participants. Prior to participation, all individuals provided informed consent after receiving a comprehensive explanation of the study’s purpose, procedures, potential risks and benefits, and their right to withdraw at any time without penalty. The consent process was conducted in a clear and accessible manner, with opportunities for participants to ask questions and receive clarification. All data were handled with strict confidentiality, and participant anonymity was maintained throughout the study. The research protocol was reviewed and approved by Shiraz University of Medical Sciences (IR.SUMS.REC.1400.442) to ensure adherence to ethical standards and the protection of participants’ rights and well-being.

: Not applicable.

: The authors declare no competing interests.

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