Zou, Feng‑Yun
Zhao, Jia-Yuan
Zhong, Shuang‑Shuang
Yin, Bo-Ya
Ni, Yu-Xuan
Deng, Ya‑Yin
Zhou, Xiang
Luo, Xiao‑Wen
Shen, Li‑Shan
Zhang, Jia-Lu
Lin, Zhi-Ping
Zhou, Wen-Ying
Wang, Shi-Huan
Guo, Ruo‑Mi https://orcid.org/0000-0002-8207-8746
Funding for this research was provided by:
National Natural Science Foundation of China (82471567, 81801757)
Basic and Applied Basic Research Foundation of Guangdong Province (2024A1515010279, 2023A1515010256)
Article History
Received: 16 June 2026
Accepted: 8 September 2026
First Online: 13 September 2026
Declarations
Ethics approval and consent to participate: This study was approved by the Institutional Research Ethics Committee of the Third Affiliated Hospital of Sun Yat-Sen University (II2023-003-01), and written informed consent was obtained from the legal guardians of all child participants in accordance with the Declaration of Helsinki. Human MRI acquisition and fasting venous blood collection were performed under this approved protocol and in accordance with relevant institutional and national ethical requirements. The exploratory animal component used laboratory mice obtained through Jennio Biotechnology’s accredited laboratory animal facility and was approved by the Institutional Animal Care and Use Committee of The Third Affiliated Hospital of Sun Yat-Sen University and Jennio Biotechnology (Approval No. IACUC-2023-A072). No privately owned animals were used; therefore, owner consent was not applicable, and no additional field-collection permits or licenses were required.
Consent for publication: Not applicable. The manuscript does not contain identifying images or personal or clinical details that could compromise participant anonymity.
Competing interests: The authors declare no competing interests.