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Article History

Received: 15 May 2019

Accepted: 14 October 2019

First Online: 19 November 2019

Ethics approval and consent to participate

: The study was approved by the Ethics Committees of the Medical Faculty Mannheim, Heidelberg University (Ethics Approval 2016-597 N-MA) and performed according to the principles of the Declaration of Helsinki. Written informed consent was obtained from all patients willing to participate in the study.

: Not applicable.

: Prof. Peitsch served as investigator for AbbVie, Boehringer Ingelheim, Eli Lilly, Janssen-Cilag, Merck, Novartis, Pfizer and UCB Pharma; participated in a clinical trial supported by Array Biopharma and MSD; was member of advisory boards of Eli Lilly, LEO Pharma, MSD, Novartis, Pfizer and UCB Pharma; obtained honoraria from ALK-Abello, AbbVie, Biotest, BMS, Janssen-Cilag, MSD, Novartis, Pfizer, Dr. Pfleger GmbH and Roche; and received support for conferences from AbbVie, Actelion, ALK-Abello, Alma Lasers, Almirall, ARC Lasers, Asclepion, BMS, Celgene, Dermapharm, Dermasence, Galderma, GSK, Janssen-Cilag, L’Oreal, La Roche Posay, LEO Pharma, Medac, MSD, Novartis, Pierre Fabre, P&M Cosmetics, Pfizer and Roche. Dr. Schaarschmidt conducted clinical trials for Novartis, Janssen-Cilag, Merck, LEO Pharma, Abbvie, and Celgene and received financial support for participation in conferences from Abbvie, ALK-Abello, Biogen Inc. and MSD. Dr. Schmieder conducted clinical trials for Novartis, Janssen-Cilag, Merck, LEO Pharma, Boehringer-Ingelheim, Abbvie, Eli Lilly, Celgene and Pfizer, received honoraria from Novartis and Janssen-Cilag and obtained support for conferences from Abbvie, Novartis, Janssen-Cilag and Pfizer. Mrs. Corinna Bubak and Mrs. Lisa Schöben have no conflict of interest to declare. The study presented here was not supported by pharmaceutical companies, and the conflicts of interest have no impact on its content.