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Article History

Received: 21 July 2022

Revised: 22 December 2022

Accepted: 23 January 2023

First Online: 30 January 2023

Declarations

:

: The MCSA protocols have been approved by the institutional review boards (IRB) of Mayo Clinic and Olmsted Medical Center in Rochester, MN, USA. All methods were performed in accordance with the relevant guidelines and regulations. All participants provided written informed consent before participation. In the case of participants with cognitive impairment sufficient to interfere with capacity, consent was obtained from a legally authorized representative.

: Not applicable.

: Yonas E. Geda receives funding from the NIH and Roche, and served on Lundbeck Advisory Board. Maria Vassilaki has received research funding from F. Hoffmann-La Roche Ltd and Biogen and consulted for F. Hoffmann-La Roche Ltd, outside of this study; currently she receives research funding from NIH and has equity ownership in Abbott Laboratories, Johnson and Johnson, Medtronic, AbbVie, Merck, and Amgen. Ronald C. Petersen serves as a consultant for Roche, Inc., Merck, Inc., Biogen, Inc., Eisai, Inc., Genentech, Inc. Eli Lilly, Inc., and Nestle, Inc., served on a DSMB for Genentech, receives royalties from Oxford University Press and UpToDate, and receives NIH funding. The other authors declare that they have no competing interests.