Crossmark

Long-acting HIV pre-exposure prophylaxis integrated with community-based sexual and reproductive health services in South Africa (LAPIS): study protocol for a hybrid (1a) cluster randomised controlled phase 3B trial of effectiveness and implementation

Crossref DOI link: https://doi.org/10.1186/s12889-025-24889-1

Published Online: 2026-01-20

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Busang, Jacob

Zuma, Thembelihle

Chimbindi, Natsayi

Ngoma, Nqobile

Herbst, Carina

Okesola, Nonhlanhla

Dreyer, Jaco

Smit, Theresa

Bird, Kristien

Mtolo, Lucky

Behuhuma, Ngundu

Lebina, Limakatso

Hendrickson, Cheryl

Miot, Jacqui

Hanekom, Willem

Herbst, Kobus

Seeley, Janet

Copas, Andrew

Baisley, Kathy

Shahmanesh, Maryam

,

Luthuli, Manono

Hlongwane, Siphesihle

Nkwanyana, Sinakekelwe

Khanyile, Phindile

Mthethwa, Dumisile

Sibiya, Lindiwe

Dlamini, Minenhle

Thwala, Cyril

Ngubane, Samkelisiwe

Danisa, Priscilla

Msane, Sithembile

Zikhali, Mthobisi

Ssozi, Eva

Dubazana, Siyabonga

Jalazi, Ashley

Nkalane, Zama
Funding

Funding for this research was provided by:

Bill and Melinda Gates Foundation (INV-033650)

Wellcome Trust Early Career Fellowship (224309/Z/21/Z)

Wellcome Trust (082384/Z/07/Z)

National Institutes of Health (R01 (5R01MH114560-03))

National Institute for Health and Care Research (082384/Z/07/Z)
License Information

Text and Data Mining valid from 2026-01-20

Version of Record valid from 2026-02-16
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Article History

Received: 12 February 2025

Accepted: 11 September 2025

First Online: 20 January 2026

Declarations

:

: Not applicable.

: The authors declare no competing interests

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