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Periconceptional antibiotic use and early- to mid-pregnancy psychological distress in a nationwide birth cohort: cross-sectional analysis from the Japan Environment and Children’s Study

Crossref DOI link: https://doi.org/10.1186/s12889-025-26119-0

Published Online: 2026-01-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Matsumura, Kenta

Inano, Hitomi

Sakai, Junko

Shimada, Kanako

Tsuchida, Akiko

Inadera, Hidekuni

,

Kamijima, Michihiro

Yamazaki, Shin

Fukami, Maki

Kishi, Reiko

Hashimoto, Koichi

Sakurai, Kenichi

Ito, Shuichi

Shinohara, Ryoji

Nakayama, Takeo

Kawasaki, Ryo

Takeshima, Yasuhiro

Nagashima, Hideki

Tsuji, Mayumi

Nakamura, Kimitoshi
Funding

Funding for this research was provided by:

Ministry of the Environment, Government of Japan
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Text and Data Mining valid from 2026-01-10

Version of Record valid from 2026-03-11
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Article History

Received: 3 November 2025

Accepted: 24 December 2025

First Online: 10 January 2026

Declarations

:

: All procedures contributing to this work complied with the ethical standards of the relevant national and institutional committees on human experimentation and with the 1975 Declaration of Helsinki, as revised in 2008. The JECS protocol was reviewed and approved by the Ministry of the Environment’s Institutional Review Board on Epidemiological Studies (100910001) and the Ethics Committees of all participating institutions. Written informed consent was obtained from all participants. The present study was also approved by the Ethics Committee of the University of Toyama (R2019035).

: Not applicable.

: The authors declare no competing interests.

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