Iommi, Marica https://orcid.org/0000-0003-4589-3474
Bonifazi, Martina
Sarti, Donatella
Mei, Federico https://orcid.org/0000-0003-1887-5377
Franchi, Matteo https://orcid.org/0000-0001-9620-8057
Rossi, Marta https://orcid.org/0000-0002-3822-9279
Pompili, Marco
Prospero, Emilia https://orcid.org/0000-0002-2387-8639
Carle, Flavia
Gesuita, Rosaria https://orcid.org/0000-0002-6943-0602
Skrami, Edlira https://orcid.org/0000-0001-7940-6748
Funding for this research was provided by:
Ministero dell’Istruzione, dell’Università e della Ricerca (2022YCMF4H)
Article History
Received: 22 December 2025
Accepted: 27 February 2026
First Online: 18 March 2026
Declarations
:
: This study was a population-based observational study conducted using anonymized secondary data from the Marche Regional Cancer Registry and regional administrative health databases. According to Italian regulations, studies based exclusively on anonymized registry and administrative data do not require approval from a local ethics committee or institutional review board, nor individual informed consent. The need for ethics approval was waived in accordance with national legislation and with the competent local ethics committee, the Comitato Etico Territoriale (CET) delle Marche , as no direct patient involvement or identifiable personal data were included in the study. All data were pseudonymized prior to analysis and handled in compliance with the General Data Protection Regulation (EU Regulation 2016/679). The study was conducted in accordance with the principles of the Declaration of Helsinki and its subsequent amendments.
: Not applicable.
: The authors declare no competing interests.