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Article History

Received: 11 August 2025

Accepted: 11 March 2026

First Online: 18 March 2026

Declarations

:

: Ethical committee procedures are adhered to at all sites. Participant enrolment at any site may begin only after receiving approval from the local ethics review board. Any changes to the protocol that could affect the study’s conduct or the potential benefits to participants—including alterations to study objectives, design, population, sample size, procedures, or key administrative aspects—must be submitted to the local ethics review board as an amendment. The names of the review boards and the approval references are: Rijeka, Croatia: Ethics Committee for Biomedical Research of the Faculty of Medicine of the University of Rijeka Heerlen, ref. no. 007–08/24 − 01/21; Rotterdam, The Netherlands: Medical Ethical Committee (MEC) – Erasmus University Medical Center Rotterdam, ref. no. NL-010532; Valencia, Spain: Comité Ético de Investigación con Medicamentos del Hospital Universitario Doctor Peset de Valencia, ref. no. 129/3. Informed consent can be either collected on paper or digitally.Participants can stop their participation at any time during the study, without disclosing reasons for withdrawing.

: Not applicable.

: The authors declare no competing interests.