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Authors
Lundberg, Christina E
Adiels, Martin
Miller, Victoria
Poirier, Paul
Rangarajan, Sumathy
Lindgren, Martin
Edqvist, Jon
Mir, Hassan
Teo, Koon K
Joseph, Philip
Lear, Scott A.
Leong, Darryl P
Yusuf, Salim
Dagenais, Gilles R.
Rosengren, Annika
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Funding
Funding for this research was provided by:
University of Gothenburg
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Article History
Received: 18 December 2025
Accepted: 26 May 2026
First Online: 2 June 2026
Declarations
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: In accordance with the Helsinki Declaration, the PURE study was coordinated by the Population Health Research Institute (Hamilton, Canada) and was approved by the Hamilton Integrated Research Ethics Board. In addition, ethical approval was obtained from local ethics committees at all participating study sites. Informed consent was obtained from all individual participants included in the study.
: Not applicable.
: KT report grants from the Canadian Institutes of Health Research. SY, SR, and DL report grants from the Canadian Institutes of Health Research and the Ontario Ministry of Health and Long-Term Care during the conduct of the study. SY reports a grant from the Marion W Burke Endowed Chair of the Heart and Stroke Foundation of Canada. PJ receives salary support through a McMaster University, Department of Medicine, Mid-Career Award. AR report grants from the Swedish state under the Agreement Concerning Research and Education of Doctors; the Swedish Heart and Lung Foundation; the Swedish Research Council; the Swedish Council for Health, Working Life and Welfare, King Gustaf V and Queen Victoria Freemason’s Foundation, and AFA Insurance. All other authors declare no competing interests.
