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Article History

Received: 5 May 2018

Accepted: 5 June 2019

First Online: 18 June 2019

Ethics approval and consent to participate

: In Belgium, the protocol has been submitted to the central Ethic Committee (EC) from the University Hospital of Liege and appropriate local ethical committee on September 9th 2014 and approved by November 12th 2014 (B707201422130–2014/247). In France, the protocol has been submitted to the Comité de Protection des Personnes Iles-de France IV and to the French competent authorities (ANSM) as Biomedical Research on February 25th 2015. Approval has been obtained on April 10th 2015 (2015/11) and May 6th 2015(2015-A00370–49), respectively. The study was conducted in strict accordance with the declaration of Helsinki and GCP principles. Each patient received and signed an informed consent.

: Not applicable.

: HY is the founder of Artialis SA a spin-off company of the University of Liège. He also received fees from Flexion, Ibsa, Expansciences, KiOmed Pharma SA (formerly Synolyne Pharma SA), Nestle, GSK, Tilman SA, Bepharbel, Labhra and Fidia Farmaceutici. BR received consulting fees from Fidia Farmaceutici. BJ received consulting fees from Kiomed Pharma. PR received fees from Artialis, IBSA, Bioiberica, Fidia, Expanscience, Genevrier, Sanofi, Servier, Flexion, Pfizer, Rottapharm, Daichi-Sankyo.The authors have no conflict of interest. The other authors did not disclaim conflict of interest.