Zucker, B. E. http://orcid.org/0000-0002-8085-9186
Ebsim, R. http://orcid.org/0000-0002-1875-5503
Lindner, C. http://orcid.org/0000-0001-9396-3436
Hardcastle, S. http://orcid.org/0000-0002-5959-4873
Cootes, T. http://orcid.org/0000-0002-2695-9063
Tobias, J. H. http://orcid.org/0000-0002-7475-3932
Whitehouse, M. R. http://orcid.org/0000-0003-2436-9024
Gregson, C. L. http://orcid.org/0000-0001-6414-0529
Faber, B. G. http://orcid.org/0000-0003-4102-0190
Hartley, A. E. http://orcid.org/0000-0003-4932-1588
Funding for this research was provided by:
Wellcome Trust (223267/Z/21/Z, 20378/Z/16/Z)
Royal Society (223267/Z/21/Z)
NIHR Bristol Biomedical Research Centre
Medical Research Council (MR/S021280/1)
Article History
Received: 8 April 2022
Accepted: 22 June 2022
First Online: 6 August 2022
Declarations
:
: Ethics approval and written informed consent was obtained in line with the Declaration of Helsinki. The study was approved by the Bath Multi-centre Research Ethics Committee (REC reference 05/Q2001/78) and each local NHS REC. Follow up data collection was approved by the Central Bristol REC and NHS Health Research Authority. All methods were performed in accordance with the relevant guidelines and regulations.
: All participants provided written informed consent at time of recruitment.
: The authors have no competing interests to disclose.