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Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration

Published Online: 2024-04-23

Authors

Wang, Peigeng

Li, Zhencong

Ye, Dongping
Funding

Funding for this research was provided by:

Guangzhou Municipal Science and Technology Project (202102010111)
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Text and Data Mining valid from 2024-04-23

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Article History

Received: 15 September 2023

Accepted: 20 March 2024

First Online: 23 April 2024

Declarations

:

: In this study, degenerated nucleus pulposus tissue samples came from an 81-year-old patient diagnosed with lumbar disc herniation/lumbar disc degeneration, and normal nucleus pulposus tissue samples came from an 11-year-old patient diagnosed with acute spinal cord injury. Fresh specimens collected at the time of surgical resection were collected in MACS tissue stock (Miltenyi Biotec, Germany) and sent to the laboratory as soon as possible. Informed consent was obtained from all subjects and/or their legal guardian(s). Patient or family has signed an informed consent. The study was approved by the Guangzhou Red Cross Hospital ethics committee.

: NA (Not Applicable).

: The authors have no conflicts of interest to declare.

: The authors declare no competing interests.

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