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Intra-articular injection of umbilical cord–derived mesenchymal stem cells is safe and effective for moderate to severe knee osteoarthritis with synovitis: a double‑blinded and randomized controlled trial

Crossref DOI link: https://doi.org/10.1186/s12891-025-09440-y

Published Online: 2025-12-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Tong, Wei

Shi, Yangyang

Wu, Dongcheng

Jia, Jie

Xiang, E

Xu, Dongdong

Rao, Wei

Hu, Qin

Liao, Qiwen

Xiao, Cuihong

Zheng, Shuo

Xu, Weihua

Tian, Hongtao
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Text and Data Mining valid from 2025-12-29

Version of Record valid from 2026-01-30
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Article History

Received: 14 June 2024

Accepted: 17 December 2025

First Online: 29 December 2025

Declarations

:

: All procedures performed in studies involving human participants were in accordance with the Helsinki Declaration of 1975, an revised in 2008. Informed consent was obtained from all patients. This trial was approved by the ethics committee of Wuhan Union Hospital (2019SC02).

: Not applicable.

: The authors declare no competing interests.

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