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A randomized, double-blind, placebo-controlled multicenter study for evaluating the effects of fixed-dose combinations of vitamin C, vitamin E, lysozyme, and carbazochrome on gingival inflammation in chronic periodontitis patients

Crossref DOI link: https://doi.org/10.1186/s12903-019-0728-2

Published Online: 2019-03-07

Published Print: 2019-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hong, Ji-Youn

Lee, Jung-Seok

Choi, Seong-Ho

Shin, Hyun-Seung

Park, Jung-Chul

Shin, Seung-Il

Chung, Jong-Hyuk http://orcid.org/0000-0002-2678-1525
Funding

Funding for this research was provided by:

Myung-In Pharmaceutical
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Article History

Received: 12 September 2018

Accepted: 20 February 2019

First Online: 7 March 2019

Ethics approval and consent to participate

: This study adhered to CONSORT guidelines and was conducted in accordance with the World Medical Association Helsinki Declaration (Version 2008). The study protocol was approved by each of the involved Institutional Review Boards (IRBs) at Kyung Hee University Dental Hospital (KHDIRB1409–2), Yonsei University Hospital (2014–0074), and Dankook University Hospital (H-1411/011/003). All the participants were informed of the objectives, interventions, and possible risks and benefits of the study prior to enrollment, and written consent was obtained.

: Not applicable.

: The authors declare that they have no competing interests.

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