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Comparing cryotherapy and ketorolac tromethamine against room-temperature saline irrigation using interleukin-8 levels and post-operative pain within single-visit endodontic treatment of symptomatic irreversible pulpitis superimposed by apical periodontitis; a comparative randomized controlled trial

Crossref DOI link: https://doi.org/10.1186/s12903-025-07347-7

Published Online: 2025-12-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ezzat, Yousra Khaled

Diab, Alaa

Shaker, Olfat

Abouelenien, Sarah
Funding

Funding for this research was provided by:

Cairo University
License Information

Text and Data Mining valid from 2025-12-12

Version of Record valid from 2025-12-27
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Article History

Received: 29 June 2025

Accepted: 14 November 2025

First Online: 12 December 2025

Declarations

:

: The informed consent forms and the protocol were reviewed and approved by the applicable IRBs/ECs [Institutional Review Boards/Ethical Committees] at the Faculty of Dentistry, Cairo University with respect to scientific content and compliance with applicable research and human subjects’ regulations (approval code: 47:9:20). The methods used in this study were in compliance with the 2013 revision of the World Medical Association’s Declaration of Helsinki. Informed consent for trial participation was obtained from all patients involved in the study.

: Not applicable.

: The authors declare no competing interests.

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