Document is current

Article History

Received: 23 September 2025

Accepted: 19 December 2025

First Online: 22 December 2025

Declarations

:

: All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and national research committees and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Our provisional plan of pulp regenerative cell therapy as a clinical treatment was approved by a Category II Certified Committee for Regenerative Medicine and was officially accepted by the Japanese Ministry of Health, Labour and Welfare (approval numbers #PB3220153, and #PB4210005, approval data: 11 January 2023, and 7 July 2021) under the Act on the Safety of Regenerative Medicine. Clinical trial number: not applicable. Written informed consent was obtained from each patient after discussing the risks and benefits compared to alternative treatments (including conventional root canal therapy).

: Written informed consent was obtained from both patients for publication of their case details and any accompanying images.

: MN, NY and KI declare no competing interests. HT is a director of Air Water Aeras Bio Inc. These affiliations did not influence the conduct or outcomes of this work.