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Article History

Received: 15 June 2018

Accepted: 6 December 2018

First Online: 19 December 2018

Ethics approval and consent to participate

: Patients were informed of the full nature and purpose of the study, and provided written informed consent before entering the trial. The study was conducted in conformity with the principles of Declaration of Helsinki and Good Clinical Practice. The study was approved by the Ethics Committee of the AOU Policlinico S. Orsola-Malpighi; CE code 100/2013/U/Sper and by the Ethics Committee of the ASST Spedali Civili di Brescia; CE code NP2047.

: All patients gave explicit written consent for data publication in aggregated form.

: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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