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Nano-formulated pomegranate extracts with dual cytotoxic and antimicrobial activity: molecular docking and mechanistic insights into leukemia cell targeting

Crossref DOI link: https://doi.org/10.1186/s12906-026-05291-9

Published Online: 2026-02-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hamdy, Naglaa M. https://orcid.org/0000-0002-8328-0081
Ismail, Ahmed https://orcid.org/0000-0003-0266-8760
Sherkawy, Hoda S. https://orcid.org/0000-0001-7508-0146
Yassin, Ayman S. https://orcid.org/0000-0003-4264-0981
Amin, Mohamed M. https://orcid.org/0000-0002-8028-7368
El-Tantawy, Hanan M. https://orcid.org/0009-0009-8219-864X
Saleh, Abdulrahman M. https://orcid.org/0000-0002-5153-7399
El-Khazragy, Nashwa https://orcid.org/0000-0001-6646-4674
Funding

Funding for this research was provided by:

Ain Shams University
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Text and Data Mining valid from 2026-02-26

Version of Record valid from 2026-03-03
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Article History

Received: 29 June 2025

Accepted: 2 February 2026

First Online: 26 February 2026

Declarations

:

: No specific ethical approval or permissions were required for this study. The plant material (Punica granatum L. cv. Assiuty) was obtained from commercial markets in Assiut and New Valley governorates, Egypt. As the samples were sourced from cultivated produce and not collected from wild populations or protected areas, no formal botanical identification or voucher specimen deposition was necessary.Experiments were conducted on the commercially available THP-1 human leukemia cell line (sourced from ATCC); therefore, no ethical approval or informed consent was required in accordance with institutional and international guidelines.

: The authors declare no competing interests.

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