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Article History

Received: 18 January 2021

Accepted: 4 August 2021

First Online: 6 September 2021

Declarations

:

: The study was conducted in accordance with the amended Declaration of Helsinki. Ethical approval for this study was obtained from each participating site according to Italian Regulation applicable for prospective observational studies. The patients provided written informed consent to their involvement in the study.The study was approved by the Ethic Committee of the coordinating center (A.O.U. Pisana Ospedale Santa Chiara, Pisa, Italy).

: The patients provided written informed consent to publication of their case details. No patients under 18 years old were involved in the study.

: Dr. Colombo reports she is a part-time employee of Novartis Farma S.p.A, Italy.Dr. Bianchi reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Fabbrocini reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Corrao reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Offidani reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; personal fees from Abbvie, personal fees from Alfasigma, personal fees from Almirall, personal fees from Amgen, personal fees from Difa Cooper, personal fees from Eli Lilly, personal fees from Janssen, personal fees from Leo Pharma, personal fees from Novartis, personal fees from Sanofi, outside the submitted work.Dr. Stingeni reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Costanzo reports grants and personal fees from Novartis Farma S.p.A, Italy, grants and personal fees from Abbvie, grants and personal fees from Lilly, personal fees from UCB, personal fees from Galderma, grants and personal fees from Leo Pharma, during the conduct of the study.Dr. Pellacani reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Peris reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; personal fees from Almirall, personal fees from AbbVie, personal fees from Biogen, personal fees from Lilly, personal fees from Celgene, personal fees from Galderma, personal fees from Leo Pharma, personal fees from Novartis, personal fees from Pierre Fabre, personal fees from Sanofi, personal fees from Sandoz, personal fees from Sun Pharma, personal fees from Janssen, outside the submitted work.Dr. Bardazzi reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr.Argenziano reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Ruffolo reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Dapavo reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; grants and personal fees from Novartis, grants and personal fees from Lilly, grants and personal fees from LEOPharma, grants and personal fees from Abbvie, grants and personal fees from Amgen, grants and personal fees from Janssen, grants and personal fees from UCB, grants and personal fees from Sandoz, outside the submitted work.Dr. Carrera reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; grants and personal fees from Abbvie, grants and personal fees from Janssen, grants and personal fees from Novartis, grants and personal fees from Lilly, grants and personal fees from Almirall, grants and personal fees from LEOPharma, outside the submitted work.Dr. Fargnoli reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; grants and personal fees from Almirall, grants and personal fees from Abbvie, grants and personal fees from Galderma, grants and personal fees from Leo Pharma, grants and personal fees from Mylan, grants and personal fees from Medac Pharma, grants and personal fees from Celgene, grants and personal fees from Pierre Fabre, grants and personal fees from UCB, grants and personal fees from Eli Lilly, grants and personal fees from Pfizer, grants and personal fees from Janssen, grants and personal fees from Novartis, grants and personal fees from Sanofi-Genzyme, grants and personal fees from Roche, grants and personal fees from Sunpharma, grants and personal fees from MSD, outside the submitted work.Dr. Parodi reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; grants from Almirall, grants from Abbvie, grants from Amgen, grants from Janssen-Cilag, grants from Novartis, grants from Eli-Lilly, grants from Leo-Pharma, grants from Galderma, grants from Pfizer, outside the submitted work.Dr. Romanelli reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Malagoli reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; personal fees from Lilly, personal fees from Novartis, personal fees from Janssen, personal fees from Abbvie, personal fees from Ucb, personal fees from LEOPharma, personal fees from Almirall, outside the submitted work.Dr. Talamonti reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Megna reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Raspanti reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Paolinelli reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Hansel reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Narcisi reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; grants and personal fees from Janssen, grants and personal fees from Novartis, grants and personal fees from Abbvie, grants and personal fees from Lilly, grants and personal fees from LEOPharma, grants and personal fees from UCB, grants and personal fees from Pfizer, grants and personal fees from Celgene, outside the submitted work.Dr. Conti reports grants from Novartis Farma S.p.A, Italy, personal fees from Eli Lilly, personal fees from UCB, personal fees from Leo Pharma, personal fees from Sandoz, personal fees from Biogen, personal fees from Janssen Cilag, personal fees from Abbvie, during the conduct of the study.Dr. De Simone reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; personal fees from Abbvie, personal fees from Almirall, personal fees from Eli Lilly, personal fees from Janssen, personal fees from Celgene, personal fees from UCB Pharma, outside the submitted work.Dr. Chessa reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. De Rosa reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Provenzano reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Ortoncelli reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Moltrasio reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Fidanza reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; grants and personal fees from Novartis, grants and personal fees from Abbvie, outside the submitted work.Dr. Burlando reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study.Dr. Tonini reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; grants and personal fees from Novartis Farma S.p.A, Italy, grants and personal fees from Janssen Cilag S.p.A., Italy, grants from Eli Lilly Italia S.p.A, Italy, grants and personal fees from Almirall S.p.A, Italy, grants from AbbVie S.r.l, Italy, outside the submitted work.Dr. Gaiani reports grants from Novartis Farma S.p.A, Italy, during the conduct of the study; personal fees and non-financial support from Abbvie, personal fees and non-financial support from ELI LILLY, personal fees and non-financial support from Novartis, non-financial support from Celgene, personal fees from LeoPharma, personal fees from Admirall, outside the submitted work.Dr. Simoni and Dr. Zullo are employees of MediNeos Observational Research (Modena, Italy), hired by Novartis Farma Italy, responsible for the design and conduction of the CANOVA study, as well as scientific support, clinical operations, data management, statistical analysis.Dr. Fiocchi and Dr. Zagni report that they are employees of Novartis Pharma, Italy.No further CoI were declared.